Many terrestrial animal and plant species are used by humans for food and medicine. These species make significant contributions to diet and healthcare, particularly in developing countries. An estimated 50,000–70,000 plant species are used in traditional and modern medicine. Many of the wild species used for food and medicine are threatened with extinction, some due to over-exploitation, or different pressures such as habitat loss, disease or a combination of factors. Regardless of the causes, the diminishing availability of these resources threatens the income from wild collection, health and well-being of the people who depend on them.