Born in Latin America, Conditional Cash Transfer (CCT) programmes target poor families, offering cash subsidies in exchange for a commitment by households to invest in the human capital of their children. Backed up by country examples, this Guide provides an overview to CCT programmes in Latin America, including their history, objectives and use, evidence of their impact, and finally, the main lessons coming out of Latin America that can be useful for policymakers considering implementing CCTs in their own countries.