These Guidelines are designed to assist government officials, policy-makers, programme managers, trainers, and health workers in bridging the gap between traditional and biomedical health systems or in scaling up existing initiatives. The Guidelines will help those concerned to envision, plan, design, implement, evaluate and scale up initiatives that involve collaborating with traditional healers for HIV transmission prevention and care in sub-Saharan Africa. The ultimate goal of this effort is to improve access to, and quality of, health services for the clients of both systems.