In recent years, depression has been recognized as a major health problem for rural women. The purpose of this article is to describe the experience of depression in a sample of chronically ill rural women who participated in an online social-support and health education research project. Middle-aged rural women with at least one chronic condition were recruited from the western USA to participate in the Women to Women (WTW) project, a 22 week computer-based intervention of virtual support and health education. The interrelationship of depression and illness, pain, and seasonal weather variations was acknowledged; traditional and complementary healthcare treatments were discussed; relationships with healthcare providers and family and friends were described; and a variety of strategies used in coping with their depression were shared.