"Effects of climate change on health will affect most populations in the next decades and put the lives and well being of billions of people at increased risk. The UCL Lancet Commission has considered what the main obstacles to effective adaptation might be. We have focused on six aspects that connect climate change to adverse health outcomes: changing patterns of disease and mortality, food, water and sanitation, shelter and human settlements, extreme events, and population and migration. Each has been considered in relation to five key challenges to form a policy response framework: informational, poverty and equity-related, technological, sociopolitical, and institutional."