This report is the fourth in a series of reports required every 180 days through fiscal year 2010 and has been prepared in coordination with the Secretary of State, the Director of National Intelligence, the Attorney General, the Administrator of the Drug Enforcement Administration, the Administrator of the United States Agency for International Development, and the Secretary of Agriculture. This assessment complements other reports and information about Afghanistan provided to the Congress; however, it is not intended as a single source of all information about the combined efforts or the future strategy of the United States, its Coalition Partners, or Afghanistan. The information contained in this report is current as of September 30, 2010. Progress across the country remains uneven, with modest gains in security, governance, and development in operational priority areas. The deliberate application of our strategy is beginning to have cumulative effects and security is slowly beginning to expand. Although significant challenges exist, some signs of progress are evident.