Corporate social responsibility (CSR) is widely accepted as the business sector's contribution to inclusive and sustainable development. Thus, government can harness the CSR agenda in pursuit of this goal. There are several reasons why governments should seek to promote CSR: greater social and environmental sustainability, market competitiveness, economic stability, and good governance. This policy-oriented paper identifies initiatives that policy-makers in the Asia Pacific region should duly consider for promoting CSR practices, at both the regional and national levels, and spanning domestic SMEs to large MNEs. The initiatives are diverse in focus and scope, although there is one common denominator: virtually none can be enacted by government alone. Any initiative to promote sustainable and responsible business needs to be sustainable in itself, and that in turn necessitates the active engagement and tangible inputs of the business community.